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US 10,294,477 B2Granted
Compositions and methods for modulating PKK expression
AssigneeIonis Pharmaceuticals, Inc.
InventorEric E. Swayze
Life of this patent
Estimating the term…
Abstract
Disclosed herein are antisense compounds and methods for decreasing PKK mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate PKK-associated diseases, disorders, and conditions.
Claims21
A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 20 linked nucleosides and has the nucleobase sequence of SEQ ID NO:
- 570, wherein the modified oligonucleotide comprises at least 1 phosphodiester internucleoside linkage, and wherein the conjugate group is covalently linked to the modified oligonucleotide at the 5′ end of the modified oligonucleotide, and wherein the conjugate group comprises:
A modified oligonucleotide according to the following formula:
- (SEQ ID NO:
- 570).
A composition comprising a modified oligonucleotide of the following formula:
- (SEQ ID NO:
- 570) and a pharmaceutically acceptable carrier or diluent.
Dependencies are inferred from the claim text.