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US 10,294,476 B2Granted
NEAT1 as a prognostic marker and therapeutic target for prostate cancer
AssigneeCornell University
InventorsDimple Chakravarty, Mark A. Rubin
Life of this patent
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Abstract
This invention relates to diagnosis and prognosis of prostate cancer, as well as therapeutic treatment of prostate cancer. More specifically, the invention provides diagnostic and prognostic methods based on detecting nuclear enriched abundant transcript 1 (NEAT1) levels in a sample. Further provided are methods for treating prostate cancer based on targeting NEAT1 via interfering RNA.
Claims24
A method of determining the presence or risk of developing or advancing prostate cancer in a subject, comprising
- providing a predetermined cut off value, wherein the cut off value is selected from the group consisting of NEAT1 long isoform Biochemical recurrence (BCR) endpoint, NEAT1 long isoform Metastatic recurrence (MET) endpoint, NEAT 1 short isoform BCR endpoint, and NEAT 1 short isoform MET endpoint,
- detecting the level of NEAT1 in a biological sample from the subject wherein the biological sample contains prostate cells,
- comparing the level of said NEAT1 relative to the predetermined cut off value, and
- determining the presence or risk of developing or advancing prostate cancer in the subject based on an elevated level of NEAT1 in the sample as compared to the cut off value.
1 more element
A method, comprising
- detecting the level of NEAT1 in a biological sample from a subject wherein the biological sample contains prostate cells,
- comparing the level of said NEAT1 relative to a predetermined cut off value, and
- determining the presence or risk of developing or advancing prostate cancer in the subject based on an elevated level of NEAT1 in the sample as compared to the predetermined cut off value, and
- administering to the subject an interfering RNA molecule targeting NEAT1 if the level of NEAT1 in the sample is elevated as compared to the predetermined cut off value.
1 more element
Dependencies are inferred from the claim text.