Nucleic acid linker
AssigneesThe University of Tokyo, Nikon Corporation
InventorsTakanori Ichiki, Shingo Ueno, Manish Biyani, Ryo Kobayashi, Hirofumi Shiono
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Abstract
The present invention relates to a nucleic acid linker for producing a complex of mRNA, and a protein or a peptide which is encoded by the mRNA, the linker comprising: a spacer portion at the 5′-terminal; a polynucleotide portion hybridizable with at least a part of a sequence of the mRNA; and an arm portion which has a connection portion for the protein or the peptide at the 3′-terminal, in which the spacer portion, the polynucleotide portion, and the arm portion form a single strand, and in which the polynucleotide portion contains a photoreactive base derivative.
Claims7
A nucleic acid linker for producing a complex of mRNA, and a protein or a peptide which is encoded by the mRNA, comprising:
- a spacer portion at the 5′-terminal;
- a polynucleotide portion hybridizable with at least a part of a sequence of the mRNA;
- and
- an arm portion which has a connection portion for the protein or the peptide at the 3′-terminal,
- wherein the spacer portion, the polynucleotide portion, and the arm portion form a single strand, and the polynucleotide portion contains a photoreactive base derivative, wherein the photoreactive base derivative is a 3-cyanovinylcarbazole nucleoside.
Dependencies are inferred from the claim text.