Back to results
US 10,294,459 B2Granted
PRRS viruses, infectious clones, mutants thereof and methods of use
AssigneeRegents of the University of Minnesota
InventorsKay Faaberg, Jun Han, Gongping Liu, Yue Wang
Life of this patent
Estimating the term…
Abstract
This disclosure provides isolated infectious polynucleotides, such as infectious clones, having a nucleotide sequence with identity to PRRS viruses such as VR-2332, Lelystad, or others, and optionally further including a deletion in a region of ORF1 that encodes the nsp2 polypeptide.
Claims8
An isolated polynucleotide comprising a sequence having at least 88% identity to SEQ ID NO:
- 5, wherein the polynucleotide contains at least one deletion each of at least 57 consecutive nucleotides in a region corresponding to nucleotide 2061 to nucleotide 3864, and wherein the polynucleotide further comprises an exogenous polynucleotide present in the deletion.
An isolated polynucleotide comprising a sequence having at least 88% identity to SEQ ID NO:
- 6, wherein the polynucleotide contains at least one deletion each of at least 57 consecutive nucleotides in a region corresponding to nucleotide 2061 to nucleotide 3864, and wherein the polynucleotide further comprises an exogenous polynucleotide present in the deletion.
Dependencies are inferred from the claim text.