Methods and kits for cell activation

A method of activating cells, the method comprising:

• a) providing a population of cells selected from the group consisting of B cells, T cells and natural killer cells;
• b) adding a plurality of first agents, wherein the first agent comprises a cell activator attached to a first binder moiety:
• c) adding a second agent comprising a plurality of capture oligomers, wherein at least a segment of at least one of the plurality of capture oligomers is capable of associating with the first binder moiety;
• and
• d) incubating the population of cells after steps (b) and (c), whereby at least a portion of the population of cells is activated.