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US 10,294,447 B2Granted
Bioreactor with condenser
AssigneeSartorius Stedim Biotech GmbH
InventorsOscar-Werner Reif, Gerid Hellwig, Juergen Van Den Boogaard, Ute Noack
Life of this patent
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Abstract
Bioreactor with a vessel having at least one gas dissipation duct for gas discharge, the orifice of the gas dissipation duct being connected to a hydrophobic sterile filter and to a condenser arranged between them and having condensation surfaces, a turbulence generator for generating a turbulent flow is arranged in the gas dissipation duct in the region of the condenser.
Claims10
A bioreactor (1) comprising:
- a vessel (2) with a flexible wall (7);
- a gas dissipation duct (3, 3′) joined to the flexible wall (7) and extending up from an upper part of the vessel (2) for gas discharge from the vessel (2), the gas dissipation duct (3, 3′) having an orifice (8);
- a hydrophobic sterile filter (5, 5′) connected to the orifice (8) of the gas dissipation duct (3, 3′);
- and a condenser (4, 4′) arranged above the vessel (2) and between the vessel (2) and the hydrophobic sterile filter (5, 5′) so that the gas dissipation duct (3, 3′) passes through the condenser (4, 4′), an outer wall (12) arranged at a distance out from the gas dissipation duct (3, 3′) at the condenser (4, 4′) and defining an interspace (17) between the outer wall (12) and the gas dissipation duct (3, 3′), connections (18, 19) communicating with the interspace (17) for conducting coolant through the interspace (17), surfaces of the gas dissipation duct (3, 3′) in the condenser (4, 4′) being configured to define turbulence generation means (9, 9′) for generating a turbulent flow and condensation in the gas dissipation duct (3, 3′) inward of the interspace (17), wherein the surfaces of the gas dissipation duct (3, 3′) that form the turbulence generation means are above the vessel (2) and communicate gravitationally with the vessel (2) via the gas dissipation duct (3, 3′) so that condensate produced at the condenser (4, 4′) flows gravitationally down through the gas dissipation duct (3, 3′) to the vessel (2), and the vessel (2), the condenser (4, 4′) and the sterile filter (5, 5′) being integrally connected and produced from gamma-sterilizable plastic and wherein the vessel (2), the condenser (4, 4′) and the sterile filter (5, 5′) are components of a disposable apparatus.
1 more element
Dependencies are inferred from the claim text.