Method for treating a GD2 positive cancer
AssigneeApeiron Biologics AG
InventorsHans Loibner, Oliver Mutschlechner, Ruth Ladenstein, Isabel Klier
Life of this patent
Estimating the term…
Abstract
Preparations and methods for treating a GD2 positive cancer by administering a preparation comprising an anti-GD2 antibody to a patient, wherein the patient is not concomitantly treated with Interleukin-2 (IL-2), and wherein one or more treatment periods with the antibody may be preceded, accompanied, and/or followed by one or more treatment periods with a retinoid.
Claims21
A method of treating neuroblastoma in a human patient comprising administering ch14.18 antibody in at least one treatment cycle, the at least one treatment cycle comprising at least one treatment period and optionally one or more days of no administration of the ch14.18 antibody to the patient between repeated treatment periods, wherein the treatment period is one or more consecutive days when the ch14.18 antibody is administered to the patient, the ch14.18 antibody being administered in a dose of or between 10 to 20 mg/m2/day by intravenous infusion over 10 to 24 hours per day to the patient without administering IL-2 within the same one or more treatment cycles, wherein the ch14.18 antibody comprises a heavy chain and a light chain, the heavy chain having an amino acid sequence comprising SEQ ID NO:4 and the light chain having an amino acid sequence comprising SEQ ID NO:3, and wherein a neuroblastoma is treated in the patient.
Dependencies are inferred from the claim text.