Chimeric antigen receptors targeting B-cell maturation antigen

A B-cell maturation antigen (BCMA) specific chimeric antigen receptor (CAR) comprising an extracellular ligand-binding domain, a first transmembrane domain, and an intracellular signaling domain, wherein the extracellular domain comprises a single chain Fv fragment (scFv) comprising a heavy chain variable (VH) region comprising three complementarity determining regions (CDRs) comprising the sequences shown in SEQ ID NO:

• 33, 72, 39, 76, 83, 92, 25, 112, or 8 of Table 1;
• and a light chain variable (VL) region comprising three CDRs comprising the sequences shown in SEQ ID NO:
• 34, 73, 40, 77, 84, 93, 18, 38, or 80 of Table 1, wherein the first transmembrane domain comprises a CD8α chain transmembrane domain, and wherein the intracellular signaling domain comprises a CD3ζ signaling domain and/or a 4-1BB signaling domain.