Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists

An isolated antigen binding protein that specifically binds to a human gastric inhibitory peptide receptor (GIPR) polypeptide, wherein said antigen binding protein is an antibody or a fragment thereof, and wherein said antibody comprises a CDRL1, a CDRL2, a CDRL3, a CDRH1, a CDRH2, and a CDRH3 wherein said. CDRL1 comprises SEQ ID NO:

• 702 ;
• said CDRL2 comprises SEQ ID NO:
• 859;
• said CDRL3 comprises SEQ ID NO:
• 1016;
• said CDRH1 comprises SEQ ID NO:
• 1173;
• said CDRH2 comprises SEQ ID NO:
• 1330;
• and said CDRH3 comprises SEQ ID NO:
• 1487.