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US 10,294,286 B2Granted
Chimeric inhibitor molecules of complement activation
AssigneeOmeros Corporation
InventorsPeter Garred, Tina Hummelshoj Glue, Mikkel-Ole Skjodt
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Abstract
The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases. The present invention further relates to nucleic acid molecules encoding such fusion polypeptides, vectors and host cells used in the production of the fusion polypeptides.
Claims10
A chimeric molecule of a ficolin-associated polypeptide comprising:
- a) a human ficolin-associated polypeptide comprising the amino acid sequence set forth in SEQ ID NO:
- 1 or a variant thereof having at least 80% sequence identity to the amino acid sequence set forth in SEQ ID NO:
- 1;
- and
- b) an immunoglobulin molecule or part thereof.
2 more elements
Dependencies are inferred from the claim text.