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AssigneesVGX Pharmaceuticals, Inc., The Trustees of the University of Pennsylvania
InventorsDavid B. Weiner, Bernadette Ferraro, Jian Yan, Patricia A. Brown, Rodney A. Bowling, Douglas R. Kern, Mathura P. Ramanathan, Niranjan Y. Sardesai, Karuppiah Muthumani
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Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
An isolated nucleic acid comprising a nucleic acid sequence encoding a protein comprising a consensus VP1 of Asia subtype of FMDV and a consensus VP1 of O subtype of FMDV, wherein the protein is selected from the group consisting of:
A composition comprising one or more proteins selected from the group consisting of SEQ ID NO:
Dependencies are inferred from the claim text.