Site-selective functionalization of glycopeptide antibiotics

A compound of Formula II:

• wherein:
• each of X1-X4 and X7 is independently selected from the group consisting of hydrogen, Br, Cl, I, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, primary amine, or secondary, amine, alkoxy, thioether, formyl, acyl, or carboxylic acid, wherein at least one of X1-X4 is not hydrogen,
• X5 and X6 are independent selected from the group consisting of hydrogen, Br, Cl, I, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, amino, primary amine, or secondary, amine, alkoxy, thioether, formyl, acyl, or carboxylic acid,
• W, Y, and Z are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, and carbohydrate,
• wherein if the compound is ristocetin and X3 is I, then X1 and/or X2 are other than hydrogen and/or X5 and/or X6 are other than chlorine, and
• wherein X3 and/or X6 is aryl or wherein X3 and/or X6 is alkenyl.