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US 10,294,272 B2Granted
Peptides with antagonistic activities against natural CXCR4
AssigneePharis Biotec GmbH
InventorsWolf-Georg Forssmann, Frank Kirchhoff, Jan Münch, Ludger Ständker
Life of this patent
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Abstract
A peptide effective in blocking the CXC-chemokine receptor 4 (CXCR4) mediated HIV-1 NL4-3 (X4-tropic) infection with an IC50 value of less than 50 μM.
Claims11
A peptide having at least one of the amino acid sequences selected from the group consisting of SEQ ID NO:
- 13, SEQ ID NO:
- 15, SEQ ID NO:
- 5,SEQ ID NO:
- 2, SEQ ID NO:1, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, and SEQ ID NO:
- 6.
8 more elements
Dependencies are inferred from the claim text.