Dipeptidyl ketoamide compounds and their use for the treatment and/or prevention of fat accumulation

A method of (i) treating and/or preventing an obesity-related condition selected from the group consisting of obesity, lipid storage disease, and hyperlipemia in a subject in need thereof, and/or (ii) reducing fat accumulation in a subject which does not suffer from obesity, said method comprising administering to said subject a therapeutically effective amount of a compound of formula (II)

• wherein
• X is selected from the group consisting of a single bond, an oxygen atom and a —NH— group;
• when X is O, R1a is selected from the group consisting of a1) C1-8 alkyl, optionally substituted by one C1-8 alkoxy group, b1) C6-10 aryl-C1-4 alkyl and c1) C5-10 heteroaryl-C1-4 alkyl wherein the C5-10 heteroaryl ring system comprises 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur,
• when X is a single bond, R1a is selected from the group consisting of d1) phenyl optionally substituted by 1 to 3 substituents selected from the group consisting of OH, NR5R6, CN, CF3, C1-6 linear or branched alkyl, C1-6 linear or branched alkoxy and halogen atoms;
• e1) naphthyl optionally substituted by 1 to 3 substituents selected from the group consisting of OH, NR5R6, CN, CF3, C1-6 linear or branched alkyl, C1-6 linear or branched alkoxy and halogen atoms;
• f1) C5-10 heterocyclyl-C0-2 alkyl wherein the heterocyclyl ring system comprises 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur and is optionally substituted by 1 to 3 substituents selected from the group consisting of OH, NH2, CN, CF3, C1-6 linear or branched alkyl and halogen atoms;
• g1) C1-6 linear or branched alkyl, optionally substituted by one C1-8 alkoxy group;
• and h1) C3-6 cycloalkyl-C0-2 alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of OH, NR5R6, CN, CF3, C1-6 linear or branched alkyl and halogen atoms;
• when X is a —NH— group, R1a is selected from the group consisting of d2) phenyl optionally substituted by 1 to 3 substituents selected from the group consisting of OH, NH2, CN, CF3, C1-6 linear or branched alkyl and halogen atoms;
• e2) naphthyl optionally substituted by 1 to 3 substituents selected from the group consisting of OH, NH2, CN, CF3, C1-6 linear or branched alkyl and halogen atoms;
• f2) C5-10 heterocyclyl-C0-2 alkyl wherein the heterocyclyl ring system comprises 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur and is optionally substituted by 1 to 3 substituents selected from the group consisting of OH, NR5R6, CN, CF3, C1-6 linear or branched alkyl and halogen atoms;
• g2) C1-6 linear or branched alkyl, optionally substituted by one C1-8 alkoxy group and h2) C3-6 cycloalkyl-C0-2 alkyl optionally substituted by 1 to 3 substituents selected from the group consisting of OH, NR5R6, CN, CF3, C1-6 linear or branched alkyl and halogen atoms;
• R2a is selected from the group consisting of ii) C1-8-alkyl optionally substituted with 1, 2 or 3 fluor atoms, j1) C1-8 alkoxy-C1-8 alkyl, and k1) C3-6 cycloalkyl-C0-2 alkyl, wherein the cycloalkyl ring is optionally substituted with 1, 2 or 3 fluor atoms, with the proviso that when X is 0 then R2a is not an isopropyl group;
• R3a is selected from the group consisting of l1) C1-8-alkyl and m1) benzyl optionally substituted by 1 to 3 substituents selected from the group consisting of C1-4-alkyl, MeO, CN and halogen atoms,
• with the proviso that when X is a single bond and R1a is a C5-10 heterocyclyl-C0-2 alkyl group, R3a is not an ethyl group;
• R4a is selected from the group consisting of n1) C1-8-alkyl, o1) C3-6 cycloalkyl-C0-2 alkyl optionally substituted by C1-4-alkyl and p1) C1-8-alkoxy;
• and
• R5 and R6 are independently selected from the group consisting of hydrogen atoms and C1-6 linear or branched alkyl groups;
• or a pharmaceutically acceptable salt thereof.