Functionalized bile acids for therapeutic and material applications
AssigneeInternational Business Machines Corporation
InventorsJames L. Hedrick, Nathaniel H. Park
Life of this patent
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Abstract
The subject disclosure is directed to functionalized bile acids, preparation thereof, and usage thereof for therapeutic and material applications. In one embodiment, a method of generating functionalized bile acid materials can comprise directly activating a carboxylic acid of a bile acid compound using a coupling agent comprising an amide or ester compound, thereby generating an intermediate bile acid derivative material. The method can further comprise attaching a functional group material to the intermediate bile acid derivative material by reacting the functional group material and the intermediate bile acid derivative material, thereby generating a functionalized bile acid material.
Claims17
A method for a synthesis of functionalized bile acid material, the method comprising:
- directly activating a carboxylic acid of a bile acid compound using a coupling agent that comprises pentafluorophenyl carbonate, thereby generating an intermediate bile acid derivative material, wherein the bile acid compound is selected from a group consisting of cholic acid, chenodeoxycholic acid, lithocholic acid, and deoxycholic acid;
- and
- covalently bonding a nucleophile to the intermediate bile acid derivative material, wherein the nucleophile comprises an amine functional group, thereby generating the functionalized bile acid material.
A method for a synthesis of functionalized bile acid material, the method comprising:
- generating an intermediate bile acid derivative material by directly activating a carboxylic acid of a bile acid compound using a coupling agent that comprises pentafluorophenyl carbonate, wherein the bile acid compound is selected from a group consisting of cholic acid, chenodeoxycholic acid, lithocholic acid, and deoxycholic acid;
- and
- generating a functionalized bile acid material using the intermediate bile acid derivative material, wherein the functionalized bile acid material comprises a chemical structure of structure I:
- wherein R corresponds to a steroid backbone, and
- wherein X corresponds to a nucleophile comprising an amine functional group.
A lithocholic acid functionalized polycarbonate, comprising:
- lithocholic acid covalently bonded with an AB diblock polycarbonate copolymer via a nucleophile comprising a quaternary amine bonded to a polycarbonate structure of the AB diblock polycarbonate copolymer.
Dependencies are inferred from the claim text.