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US 10,294,254 B2Granted
DNA/Dithiocarbamato phosphine metal complex
AssigneesKing Fahd University of Petroleum and Minerals, King Saud University
InventorsSaid S. Al-Jaroudi, Ali Alhoshani, Muhammad Altaf, Anvarhusein Abdulkadir Isab
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Abstract
Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.
Claims5
A DNA/dithiocarbamato(phosphine)metal complex, comprising:
- a dithiocarbamato(phosphine)gold(I) compound represented by formula (I):
- a salt thereof, a solvate thereof, or a combination thereof;
- and
- DNA complexed to the dithiocarbamato(phosphine)gold(I) compound;
- wherein R1 and R2 are alkyl groups independently selected from the group consisting of methyl, ethyl, and isopropyl;
- R3, R4, and R5 are independently selected from the group consisting of an optionally substituted C1-C3 alkyl, an optionally substituted arylalkyl, an optionally substituted aryl, an optionally substituted vinyl, an optionally substituted alkoxy, and an optionally substituted aryloxy;
- and
- with the proviso that R1, R2, R3, R4, and R5 are not each an ethyl.
5 more elements
Dependencies are inferred from the claim text.