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US 10,294,240 B2Granted
Fluorescent probe for detecting calpain activity
AssigneesThe University of Tokyo, Tohoku University
InventorsYasuteru Urano, Yuri Nagayo, Mako Kamiya, Toru Nakazawa
Life of this patent
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Abstract
[Problem] To provide a fluorescent probe that detects calpain activity in cells at high sensitivity. [Solution] A compound represented by the following general formula (I) or a salt thereof.
Claims8
A compound of the following general formula (I):
- wherein R1 is a hydrogen atom or from one to four of the same or different substituents that bond to the benzene ring;
- R2, R3, R4, R5, R6, and R7 are, each independently, a hydrogen atom, hydroxyl group, alkyl group, or halogen atom;
- R8 and R9 are, each independently, a hydrogen atom or alkyl group;
- X is a C1-C3 alkylene group;
- R10 is selected from the following formula (1) or (2);
- or a salt thereof.
3 more elements
A compound of the following formula (3) or a salt thereof
A compound of the following formula (4) or a salt thereof
Dependencies are inferred from the claim text.