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US 10,294,230 B2Granted
3,3-difluoropiperidine carbamate heterocyclic compounds as NR2B NMDA receptor antagonists
AssigneeRugen Holdings (Cayman) Limited
InventorGideon Shapiro
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Abstract
Disclosed are chemical entities of Formula (I): wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).
Claims28
A chemical entity, which is a compound of formula:
- wherein:
- R5 is selected from the group consisting of —H, —CH3, —F, —Cl, —CH2CH3, —CF2H, —CH2F, —CF3, —CF2CH3, —CH2CF3, cyclopropyl, —OCF3, —OCF2H, —SCH3, —SO2CH3, and ethynyl;
- R6 is selected from the group consisting of —H and —F;
- R7 is selected from the group consisting of —H, —F, —Cl, and —CH3;
- and
- Z is
3 more elements
Dependencies are inferred from the claim text.