Heteroaryl substituted aminopyridine compounds

A compound of Formula (I)

• or a salt thereof, wherein:
• HET is a heteroaryl selected from pyrrolo[2,3-b]pyridinyl, pyrrolo[2,3-d]pyrimidinyl, pyrazolo[3,4-b]pyridinyl, pyrazolo[3,4-d]pyrimidinyl, imidazolo[4,5-b]pyridinyl, and imidazolo[4,5-d]pyrimidinyl, wherein said heteroaryl is attached to the pyridinyl group in the compound of Formula (I) by a nitrogen ring atom in said heteroaryl and wherein said heteroaryl is substituted with zero to 2 Rb;
• A is pyrazolyl, imidazolyl, triazolyl, isoxazolyl, oxadiazolyl or dihydroisoxazolyl, each substituted with Ra;
• R3 is C2-3 alkyl, C2-3 fluoroalkyl, C3-4 hydroxyalkyl, or a cyclic group selected from C3-6 cycloalkyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, and pyrazolyl, wherein said cyclic group is substituted with zero to 2 substituents independently selected from F, —OH, C1-2 alkyl, and —CH2CHF2;
• Ra is:
• (i) H, F, Cl, —OH, —CN, C1-6 alkyl, C1-6 fluoroalkyl, C1-4 cyanoalkyl, C1-6 hydroxyalkyl, C1-5 hydroxy-fluoroalkyl, C2-4 alkenyl, C1-6 aminoalkyl, —(CH2)1-3NHRy, —(CH2)1-3NRyRy, —CH2CH(OH)(phenyl), —CH(CH2OH)(phenyl), —CH2CH(OH)CH2(phenyl), —CH2CH(OH)CH2O(methoxyphenyl), —CH2CH(NH2)CH2(phenyl), —(CH2CH2O)4H, —(CH2)1-3O(C1-3 alkyl), —CH2CH(OH)CH2O(C1-3 alkyl), —CH2C(O)(C1-3 alkyl), —CH2C(O)NRyRy, —(CH2)1-3NRyC(O)(C1-3 alkyl), —CH2C(O)O(C1-3 alkyl), —C(O)NH2, —CH2NRyC(O)NH2, —(CH2)1-2NRyC(O)O(C1-2 alkyl), —(CRyRy)1-5OC(O)CH2NRyRy, —CH2CH2S(O)2CH3, —CH2S(O)2(C1-3 alkyl), —CH2S(O)2(phenyl), or —NH(aminocyclohexyl);
• or
• (ii) —(CH2)0-3Rz or —(CH2)0-1C(O)Rz, wherein Rz is C3-6 cycloalkyl, azetidinyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, piperidinyl, piperazinyl, pyrrolyl, pyrrolidinonyl, morpholinyl, pyrrolidinyl, phenyl, pyrazolyl, imidazolyl, pyridinyl, pyrimidinyl, dioxopyrimidinyl, benzo[d]imidazolyl, benzo[d]thiazolyl, 1,3-dioxolanyl, or 8-azabicyclo[3.2.1]octanyl, each substituted with zero to 4 substituents independently from F, —CN, —OH, —NRyRy, C1-3 alkyl, C1-3 fluoroalkyl, C1-3 hydroxyalkyl, —CH(phenyl)2, —O(C1-4 alkyl), —C(O)(C1-4 alkyl), —C(O)(C1-4 deuteroalkyl), —C(O)(C1-5 hydroxyalkyl), —C(O)(C1-3 fluoroalkyl), —C(O)(C3-6 cycloalkyl), —C(O)O(C1-3 alkyl), —C(O)NRyRy, —C(O)(phenyl), —C(O)(pyridinyl), —C(O)CH2(C3-6 cycloalkyl), —C(O)O(C1-4 alkyl), —NH(C1-4 alkyl), —NH(C1-3 fluoroalkyl), —NHC(O)CH3, —NHC(O)O(C1-3 alkyl), —NHC(O)OC(CH3)3, —S(O)2(C1-3 alkyl), —OS(O)2(C1-3 alkyl), methyl oxadiazolyl, and pyrimidinyl;
• each Rb is independently selected from H, Cl, —CN, —NH2, and —C(O)NH2;
• and
• each Ry is independently H or C1-2 alkyl.