4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity

A compound having formula (I):

• where
• X, Y and Z are H, F, or Cl;
• R1 is OR, where R is hydrogen or a group selected from straight or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, CF3, CCl3, and aryl in positions 2, 3 or 4;
• R2 is OH, alkoxy, aryloxy, CH2OR (where R is H, linear or branched aryl, cycloalkyl or alkyl), CH2NR′R″ (where R′ and R″ are independently H, linear or branched aryl, cycloalkyl or alkyl), CHO, OCOW (where W is linear or branched aryl or alkyl or C-(halogen)3), CONR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl or aryl), COOR (where R is H, alkyl, cycloalkyl or aryl), CH2NHSO2R (where R is H, alkyl, cycloalkyl or aryl), Cl, Br, F, substituted or unsubstituted CH2—N-benzimidazole, CONHNR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl or aryl), NRCOOR′ (where R and R′ are independently H, alkyl, cycloalkyl or aryl), NH2, NR′R″ (where R′ and R″ independently are alkyl, cycloalkyl or aryl), NHCOR (where R is H, alkyl, cycloalkyl or aryl), nitro, OCH2CH2-heterocyclyl, OCOR (where R is H, alkyl, cycloalkyl or aryl), OCONR′R″ (where R′ and R″ are independently H, alkyl, cycloalkyl or aryl), OCOOR (where R is H, alkyl, cycloalkyl or aryl), NHCOOCH2C-halo3, NRCONR′R″ (where R, R′ and R″ independently are H, alkyl, cycloalkyl or aryl), NHSO2R (where R is H, alkyl, cycloalkyl or aryl), NHSO2NR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl or aryl),
• and R3 is OH, alkoxy, aryloxy, NR′R″ (where R′ and R″ are H), NHCOR (where R is H, alkyl, cycloalkyl or aryl), and CONR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl or aryl.