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US 10,294,217 B2Granted
Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators
AssigneeSuven Life Sciences Limited
InventorsRamakrishna Nirogi, Anil Karbhari Shinde, Abdul Rasheed Mohammed, Ramkumar Subramanian, Vijay Sidram Benade, Gopinadh Bhyrapuneni, Venkateswarlu Jasti
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Abstract
The present invention relates to compound of formula (I), or stereoisomers and pharmaceutically acceptable salts as muscarinic M1 receptor positive allosteric modulators. This invention also relates to methods of making such compounds and pharmaceutical compositions comprising such compounds. The compounds of this invention are useful in the treatment of various disorders that are related to muscarinic M1 receptor. (Formula I)(I)
Claims8
A fluoroindole compound of formula (I),
- wherein:
- R1 is
- R2
- wherein * represents point of attachment;
- R3 is fluorine or hydrogen;
- R4 is halogen, S—CH3 or hydrogen;
- R5 is halogen, —O—CH3, CONH2, CONHCH3, or hydrogen;
- and
- a is 1 or 2;
- or an isotopic form, a stereoisomer or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.