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US 10,294,196 B2Granted
Process for the synthesis of intermediates useful for preparing 1,3,4-triazine derivatives
OwnerSheng Xu, YiHui Xuinventors
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Abstract
A process for the synthesis of 1,3-diethyl 2-(2-methylhydrazinylidene)propanedioate comprising the step of: reacting 2-halosubstituted diethyl malonate or mixtures of 2-halo-substituted diethyl malonates with methylhydrazine or the salt thereof in the presence of an acid catalyst is disclosed. 1,3-diethyl 2-(2-methylhydrazinylidene)propanedioate is an intermediate useful for preparing 1,3,4-triazines.
Claims13
A process for the preparation of 1,3-diethyl 2-(2-methylhydrazinylidene)propanedioate, comprising the step of:
- reacting 2-halosubstituted diethyl malonate with methylhydrazine or a salt thereof optionally in the presence of an acid catalyst.
A process for the preparation of 1,3-diethyl 2-(2-methylhydrazinylidene)propanedioate, comprising the step of:
- reacting 2-halo-substituted diethyl malonate with methylhydrazine or a salt thereof in a solvent selected from the group consisting of:
- methanol, ethanol, 1-propanol, isopropyl alcohol, acetonitrile and mixtures thereof, in the presence of a catalyst selected from the group consisting of acetic acid, hydrochloric acid, sulfuric acid, phosphoric acid and mixtures thereof, and at a temperature ranging from about 10 to about 80° C.
Dependencies are inferred from the claim text.