Delivery catheter for and method of delivering implant, for example, bronchoscopically implanting a marker in a lung

A method of deploying and tracking markers in a patient according to a radiation plan, the method comprising:

• positioning a catheter in a lumen within the patient;
• deploying a first marker at a first location proximate a treatment target within the patient, wherein deploying the first marker includes
• moving a push wire of the catheter toward a distal end of the catheter or fixing the push wire in place and retracting the catheter toward a proximal end of the push wire, and
• releasing an anti-migration device of the first marker from the catheter such that the anti-migration device anchors the first marker at the first location, the anti-migration device having a shell assembly, an anchor sleeve, a fastener, and an anchor disk;
• deploying a second marker at a second location proximate the treatment target within the patient;
• tracking at least one of position, rotation, and motion of the treatment target, wherein the tracking includes:
• collecting at least one of position, rotation, and motion data of the first and second markers during radiation treatment, and
• calculating, in real time, at least one of position, rotation, and motion of the first and second markers using the at least one of the position, rotation, and motion data of the first and second markers;
• interrupting the radiation treatment when the at least one of the position, rotation, and motion of the first and second markers exceeds a predetermined offset value;
• realigning the patient to bring the at least one of the position, rotation, and motion of the first and second markers below the predetermined offset value before continuing the radiation treatment;
• determining whether to adapt the radiation plan based on at least one of changes in the treatment target and results of the radiation plan.