Intravenous tubing set modified for in-line catheter flushing

An intravenous tubing set comprising:

• a coupling component for accessing a source of flush solution;
• a flexible evacuated flush chamber having a vacuum;
• a first IV tubing for integrally connecting the source of flush solution to the flush chamber for delivering flush solution from the source of flush solution to the flush chamber via the coupling component, wherein the first IV tubing is connected to the flush chamber by one or more heat seals;
• a first flow control device disposed in the first IV tubing between the source of flush solution and the flush chamber to control the flow of flush solution into the flush chamber, wherein the first flow control device does not come into contact with the flush solution;
• a second IV tubing integrally connecting the flush chamber to a patient catheter via one or more heat seals for delivering flush solution to the patient catheter;
• such that the source of flush solution, the flush chamber, the first IV tubing and the second IV tubing form a closed evacuated system;
• a second flow control device disposed in the second IV tubing between the flush chamber and the patient catheter, wherein the second flow control device does not come into contact with the flush solution;
• and
• a third flow control device disposed downstream from the flush chamber to close off the flush chamber during continuous IV therapy, wherein the third flow control device does not come into contact with the flush solution.