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US 10,293,084 B2Granted
Extracellular matrix (ECM) structures for tissue regeneration
AssigneeAziyo Med, LLC
InventorRobert G. Matheny
Life of this patent
Estimating the term…
Abstract
An extracellular matrix (ECM) structure for tissue regeneration, the ECM structure having a a sheet member comprising small intestine submucosa (SIS), the SIS sheet member being folded and laminated proximate the sheet member edge, wherein a folded laminated ECM structure having a cavity therein is formed, the ECM structure further including an ECM composition that is disposed in the ECM structure cavity, the ECM composition including liver basement membrane, urinary bladder submucosa, a mesenchymal stem cell and a growth factor.
Claims18
An implantable medical product, comprising:
- a bioremodelable pouch structure comprising an extracellular matrix (ECM) structure in sheet form, said ECM structure comprising acellular ECM from a decellularized mammalian tissue source, said decellularized mammalian tissue source being small intestine submucosa, liver basement membrane, stomach submucosa, urinary bladder submucosa, placental basement membrane, pancreatic basement membrane, large intestine submucosa, lung interstitial membrane, respiratory tract submucosa, heart extracellular matrix, or dermal matrix;
- said pouch structure comprising an internal cavity having an opening, wherein the pouch structure is configured to contain an additional component or composition in the internal cavity;
- wherein the ECM structure provides tensile strength to support newly forming tissue and includes first and second ECM sheets or sheet portions, each ECM sheet or sheet portion having single or plural layers and edges, wherein only the edges of the ECM sheets or sheet portions are joined together by laminating, suturing or gluing except for the edges that form the opening to provide the internal cavity that is located between the sheets or sheet portions;
- wherein the composition provided in the internal cavity of the pouch structure comprises an antibiotic or a drug or a biologically active agent,
- wherein the pouch structure effectively improves biological functions by promoting tissue regeneration, modulated healing of adjacent tissue or growth of new tissue when implanted in a body of a warm blooded mammal.
2 more elements
An implantable medical product, comprising:
- a bioremodelable pouch structure comprising an extracellular matrix (ECM) structure in sheet form, said ECM structure comprising acellular ECM from a decellularized mammalian tissue source, said decellularized mammalian tissue source being small intestine submucosa, liver basement membrane, stomach submucosa, urinary bladder submucosa, placental basement membrane, pancreatic basement membrane, large intestine submucosa, lung interstitial membrane, respiratory tract submucosa, heart extracellular matrix, or dermal matrix;
- said pouch structure comprising an internal cavity and an opening, wherein the pouch structure is configured to receive and contain an additional component or composition in the internal cavity;
- wherein the ECM structure provides tensile strength to support newly forming tissue and includes first and second ECM sheets or sheet portions, each ECM sheet or sheet portion having single or plural layers and edges, wherein only the edges of the ECM sheets or sheet portions are joined together by laminating, suturing or gluing except for the edges that form the opening to provide the internal cavity that is located between the sheets or sheet portions;
- wherein the composition provided in the internal cavity of the pouch structure effectively improves biological functions by promoting tissue regeneration, modulated healing of adjacent tissue or growth of new tissue when implanted in a body of a warm blooded mammal.
1 more element
Dependencies are inferred from the claim text.