Biological adhesives and sealants and methods of using the same
AssigneeSealantis Ltd.
InventorsOhad Kimhi, Ronit Langzam-Sinai, Havazelet Bianco-Peled, Charles Milgrom, Rina Lev
Life of this patent
Estimating the term…
Abstract
This invention provides a kit for making an adhesive and/or a sealant which includes: a first composition of alginate and a multivalent cation salt at a concentration ratio (mg/ml) of 30:1 to 1:60, and a second composition of alginate and a buffer, wherein the buffer has a pH value of between 2 to 7. The invention also provides a method for making a sealant or an adhesive, by contacting the first composition and the second composition.
Claims20
A kit comprising:
- a first component and a second component, said first component comprises a crosslinkable polysaccharide and a multivalent cation salt at a concentration ratio (mg/ml) of 30:1 to 1:60, said second component comprises a crosslinkable polysaccharide and a buffer, said buffer has a pH value of between 2 to 6 and comprises (i) an acid and (ii) its acid addition salt.
A method for forming a sealant, comprising contacting a first composition and a second composition, wherein said first composition comprises a crosslinkable polysaccharide and a multivalent cation salt at a concentration ratio (mg/ml) of 30:1 to 1:60, said second composition comprises a crosslinkable polysaccharide and a buffer, said buffer has a pH value of between 2 to 6 and comprises an acid and its acid addition salt, thereby forming a sealant.
A sealant or an adhesion barrier produced by mixing a first composition comprising a crosslinkable polysaccharide and a bivalent cation salt at a concentration ratio (mg/ml) of 30:1 to 1:60 and a second composition comprising a crosslinkable polysaccharide and a buffer, said buffer has a pH value of between 2 to 6 and comprises an acid and its acid addition salt.
A method comprising the step of:
- (a) providing a first composition and a second composition, said first composition comprises a crosslinkable polysaccharide and a multivalent cation salt at a concentration ratio (mg/ml) of 30:1 to 1:60, said second composition comprises a crosslinkable polysaccharide and a buffer, said buffer has a pH value of between 2 to 6 and comprises an acid and its acid addition salt, and optionally mixing said first composition and said second composition;
- and
- (b) applying said first composition and said second composition to the target site thereby forming an adhesion barrier in situ, wherein said adhesion barrier adheres to said target site, thereby, inhibiting, or reducing fibrosis, scarring, and/or adhesion in said target site.
Dependencies are inferred from the claim text.