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US 10,293,077 B2Granted
Polyphosphate-functionalized inorganic nanoparticles as hemostatic compositions and methods of use
AssigneesThe Regents of the University of California, The Board of Trustees of the University of Illinois
InventorsDamien Kudela, Galen D. Stucky, Anna May-Masnou, Gary Bernard Braun, James H. Morrissey, Stephanie A. Smith
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Abstract
A hemostatic composition is provided. The hemostatic composition includes a hemostatically effective amount of a hemostatic agent that includes a nanoparticle and a polyphosphate polymer attached to the nanoparticle. Also provided are medical devices and methods of use to promote blood clotting.
Claims29
A hemostatic composition comprising a hemostatically effective amount of a hemostatic agent comprising:
- a material selected from the group consisting of iron oxide, diatomaceous earth, an aluminosilicate, an oxide of a transition metal, and titanium dioxide, wherein the material is a nanoparticle;
- and
- a polyphosphate polymer covalently attached to the nanoparticle.
Dependencies are inferred from the claim text.