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US 10,293,062 B2Granted
Metal complexes with bisphosphonate useful as imaging agents
AssigneeDuke University
InventorChristopher David Lascola
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Abstract
Provided herein are magnetic resonance imaging (MRI) contrast agents comprising a compound having a structure represented by: Y—X—Z, wherein, X is: Fe(III) or Mn(II), and Y and Z are each independently selected from pyrophosphate and bisphosphonate (e.g., 1-hydroxybisphosphonate), or a pharmaceutically acceptable hydrate and/or salt thereof. Methods of use of the MRI contrast agent are also provided.
Claims20
A magnetic resonance imaging (MRI) contrast agent comprising a compound having a structure represented by:
- Y—X—Z
- wherein,
- X is Mn(II) and Y and Z are each independently a bisphosphonate of the formula:
- wherein:
- R1 is —OH, and R2 is selected from the group consisting of:
- H, alkyl, aminoalkyl, alkylaminoalkyl, arylalkyl, and heteroarylalkyl
- wherein said compound has a stoichiometry of 1:2 (Mn(II):bisphosphonate);
- wherein said compound is a salt comprising at least one alkali metal and at least one alkaline earth metal, and
- wherein the contrast agent has a molecular weight of less than 2,000 daltons.
6 more elements
Dependencies are inferred from the claim text.