Compositions for the treatment of gastrointestinal inflammation
AssigneeMeritage Pharma, Inc.
InventorsElaine Phillips, Malcolm Hill
Life of this patent
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Abstract
Provided herein are methods for treating, preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.
Claims12
A stable oral pharmaceutical composition for treating or alleviating esophageal inflammation or symptoms of esophageal inflammation in an individual, the pharmaceutical composition comprising a topically active corticosteroid, a liquid vehicle, maltodextrin in an amount of about 0.05 g to about 2 g of maltodextrin/mL of composition, and a carboxymethyl cellulose (CMC) in an amount of about 1 mg to about 150 mg of CMC/mL of composition, wherein at least 10% of the stable oral pharmaceutical composition adheres to the esophagus for at least 15 seconds after oral administration of the stable oral pharmaceutical composition, wherein the pharmaceutical composition is chemically and physically stable, and wherein the pharmaceutical composition remains substantially uniform for at least 1 day.
Dependencies are inferred from the claim text.