FGF-18 formulation in xyloglucan gels
AssigneeAres Trading S.A.
InventorsCaterina Lo Presti, Donatella Bulone, Clelia Dispenza
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Abstract
The invention relates to the field of pharmaceutical formulations. More particularly, it is directed to xyloglucan hydrogels comprising Fibroblast Growth Factor 18 (FGF-18) compounds and methods of producing such hydrogels. The hydrogels of the invention can be used, once formed in situ, for the treatment of cartilage disorders such as osteoarthritis or cartilage injury.
Claims11
A liquid formulation comprising FGF-18, a xyloglucan and a buffer keeping the pH between about 5.5 and about 6.0, wherein said xyloglucan is partially degalactosylated and wherein FGF-18 is selected from the group consisting of:
- a) a polypeptide comprising amino acid residues 28-207 of SEQ ID NO:1,
- b) a polypeptide comprising amino acid residues 28-196 of SEQ ID NO:1, and
- c) a polypeptide comprising SEQ ID NO:2.
Dependencies are inferred from the claim text.