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US 10,293,050 B2Granted
Macrolide dosage forms
AssigneeMicell Technologies, Inc.
InventorsJames B. McClain, Wenda C. Carlyle, Charles Douglas Taylor
Life of this patent
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Abstract
Provided is a drug delivery composition comprising at least one polymer and at least one active agent; wherein the active agent is present in crystalline form on at least one region of an outer surface of the composition and wherein active agent surface content is adjusted to provide a selected active agent release profile.
Claims24
A method of creating a dosage form comprising the steps of:
- providing a substrate;
- depositing a bioabsorbable polymer;
- depositing a crystalline limus drug;
- subjecting the deposited polymer and drug to an elevated temperature to create the dosage form;
- and
- releasing the dosage form from the substrate,
- wherein the dosage form provides a selected active agent controlled release profile and includes only the materials deposited according to the foregoing steps.
4 more elements
A method of creating a dosage form comprising the steps of:
- providing a substrate;
- depositing a bioabsorbable polymer;
- depositing a crystalline limus drug;
- subjecting the deposited polymer and drug to an elevated temperature to create the dosage form;
- and
- releasing the dosage form from the substrate,
- wherein the dosage form provides a selected active agent controlled release profile and is independent of other substrates.
4 more elements
A method of creating a dosage form comprising the steps of:
- providing a substrate;
- forming a first bioabsorbable polymer layer;
- forming a first crystalline limus drug layer;
- forming a second bioabsorbalbe polymer;
- subjecting the deposited polymer layers and drug layers to an elevated temperature to create the dosage form;
- and
- releasing the dosage form from the substrate,
- wherein the dosage form provides a selected active agent controlled release profile and is independent of other substrates.
5 more elements
Dependencies are inferred from the claim text.