Proteolytic extract from bromelain for the treatment of connective tissue disorders

A method of treating a connective tissue disease comprising injecting into a subject in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of a proteolytic extract obtained from bromelain and a pharmaceutically acceptable carrier, wherein the proteolytic extract comprises stem bromelain EC 3.4.22.32, ananain EC 3.4.22.31, at least one cysteine protease precursor, at least one cysteine protease fragment, and a lectin, wherein the connective tissue disease is associated with excess collagen deposition, and wherein the step of injecting is repeated two or more times.