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US 10,293,027 B2Granted
Methods for treating metabolic disorders using FGF
AssigneeThe Salk Institute for Biological Studies
InventorsJohan W. Jonker, Michael Downes, Ronald M. Evans, Jae Myoung Suh
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Abstract
The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.
Claims20
A method for treating a diabetic, hyperglycemic, and/or insulin resistant mammal, comprising administering a functional fragment of FGF-1 comprising at least 80% of human FGF-1 and an amino acid substitution at amino acid position R35 of mature human FGF-1 to the mammal in an amount effective to reduce blood glucose levels in the mammal.
Dependencies are inferred from the claim text.