Peptide inhibitors of serotonin 5-HT2C receptor:PTEN interaction
AssigneesBoard of Regents, The University of Texas Sytem, University of Houston System
InventorsKathryn Cunningham, Scott Gilbertson
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Abstract
The inventors have identified how the assembly of the 5-HT2cR with another protein (phosphatase and tensin homologue; PTEN) controls cellular function, and have synthesized a new peptide that interrupts the 5-HT2cR:PTEN complex to result in enhanced 5-HT2cR function.
Claims2
A method of activating 5-HT2c receptors (5-HT2cR) signaling comprising administering to a human having an addiction to food, drugs, alcohol, or nicotine an effective amount of a peptide having an amino acid sequence of SEQ ID NO:2 or a functional variant thereof in combination with a 5-HT2cR agonist, wherein the 5-HT2cR agonist is WAY163909 and the functional variant is a peptide that has been modified by an amino terminal modification, a carboxy terminal modification, or an amino terminal modification and a carboxy terminal modification;
- or has a single amino acid substitution within the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.