Conjugates and prodrugs for treating cancer and inflammatory diseases

A conjugate of general formula (I):

• in which:
• A represents a radical of the dolastatin family or a derivative thereof,
• L represents a radical capable of reacting with an amino, hydroxyl or thiol function,
• G comprises a glucuronyl radical or a derivative thereof,
• Y represents H, or an electron-withdrawing radical chosen from NO2, CF3 and a halogen,
• R1 and R2 represent, independently of one another, H or a linear or branched, saturated or unsaturated C1 to C10 alkyl radical,
• Z represents a hydrocarbon-based spacer radical comprising, at each of its ends, covalent bond functions,
• X represents —O— or —NR3COO—, with R3 representing a hydrogen atom or a linear or branched, saturated or unsaturated C1 to C10 alkyl radical, the bond with the G radical being provided by the oxygen atom (—O),
• an isomer thereof and/or a pharmaceutically acceptable salt thereof.