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US 10,293,018 B2Granted
Fusion protein for treating rejection reaction in transplantation
AssigneeImmunwork Inc.
InventorsTse-Wen Chang, Hsing-Mao Chu, Li-Yun Du
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Abstract
The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.
Claims4
A molecular construct comprising,
- a pair of CH2-CH3 segments of an IgG.Fc;
- a pair of effector elements, wherein each effector element is an extracellular domain of cytotoxic T lymphocyte associated protein 4 (CTLA-4) or an extracellular domain of programmed death-ligand 1 (PD-L1);
- and
- a pair of targeting elements, wherein each targeting element is an antibody fragment specific for a human leukocyte antigen (HLA) allotype present only on cells of a donor transplant and not on cells of the recipient and comprises the amino acid sequence of SEQ ID NO:
- 32 or SEQ ID NO:
- 34, wherein,
- the pair of effector elements is linked to the N-termini of the pair of CH2-CH3 segments, and the pair of targeting elements is linked to the C-termini of the pair of CH2-CH3 segments, or vice versa.
4 more elements
Dependencies are inferred from the claim text.