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US 10,293,007 B2Granted
Compositions and methods for treatment of skin disorders
AssigneeNaked Biome, Inc.
InventorsEmma Taylor, David Hanzel
Life of this patent
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Abstract
Described herein are compositions and methods of treatment for acne and other skin disorders involving the use of probiotics. In certain aspects, microbes included in the probiotics have been engineered or selected for the treatment of specific skin disorders.
Claims19
A method of treating a skin disorder or condition comprising applying to the skin of a subject in need thereof, or adding to a composition that is applied to the skin of a subject in need thereof, a pharmaceutical composition comprising:
- a) a therapeutically effective amount of a health-associated Propionibacterium acnes microbe, wherein the health-associated Propionibacterium acnes microbe is characterized by the following:
- i) it comprises at least one of a gene encoding a deoxyribose operon repressor and a gene encoding a type II lipase;
- ii) it does not comprise a pIMPLE plasmid;
- iii) it comprises at least one gene encoding an ATP binding cassette transporter;
- iv) it lacks a gene encoding a DNA binding response regulator and a gene encoding a phosphoglycerate kinase;
- and
- v) it lacks a gene encoding a CAMP2 protein;
- and
- b) a biological stabilizer.
6 more elements
Dependencies are inferred from the claim text.