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AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsLaura J. Niedernhofer, Mitra Lavasani, Paul D. Robbins, Johnny Huard
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This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or improves health of the mammal. In addition, the invention also relates to compositions containing one or more regulatory factors secreted or released from isolated mammalian stem/progenitor cells and use of such compositions to extend lifespan and/or improve health of a mammal. Also provided are methods of treating, delaying, preventing or reversing progeria or related syndromes in a mammal using isolated autologous or allogeneic stem/progenitor cells and/or regulatory factors secreted or released therefrom.
An in vitro method of ameliorating a dysfunction of muscle-derived stem/progenitor cells (MDSPCs) isolated from an aged subject, comprising
An in vitro method of restoring the myogenic differentiation capacity of muscle-derived stem/progenitor cells (MDSPCs) isolated from an aged subject, comprising contacting the MDSPCs with an exogenous amount of isolated young allogeneic MDSPCs and one or more inhibitors of mTOR and/or IKK/NF-κB pathway, thereby restoring the myogenic differentiation capacity of the MDSPCs isolated from an aged subject.
Dependencies are inferred from the claim text.