Method of inhibiting quorum sensing using D-galactose
AssigneesSeoul National University R&Db Foundation, Foundation of Soongsil University-Industry Cooperation
InventorsBong Kyu Choi, Eun Ju Ryu, Jae Hyun Sim, Byeong Moon Kim, Julian Lee, Jun Sim
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Abstract
Provided are a use of D-galactose in inhibition of quorum sensing and/or in prevention and/or treatment of oral bacterial diseases; in particular, a composition for inhibiting quorum sensing and a composition for preventing and/or treating oral bacterial diseases, the composition comprising D-galactose, and a method of inhibiting quorum sensing and a method of preventing and/or treating oral bacterial diseases, the method comprising administering D-galactose.
Claims6
A method of inhibiting quorum sensing of oral disease-causing bacteria, the method comprising administering toothpaste containing D-galactose in an amount of 0.036 to 3.6% by weight to a buccal mucosa, a tooth, a gingiva, or a tongue of a subject in need of inhibition of quorum sensing of oral disease-causing bacteria,
- wherein the oral disease-causing bacteria is Streptococcus mutans, and the D-galactose does not inhibit quorum sensing of non-pathogenic normal oral flora which is one or more selected from the group consisting of Streptococcus oralis, Streptococcus salivarius, and Streotpcoccus mitis.
A method of inhibiting quorum sensing autoinducers of oral disease-causing bacteria, the method comprising administering toothpaste containing D-galactose in an amount of 0.036 to 3.6% by weight to a buccal mucosa, a tooth, a gingiva, or a tongue of a subject in need of inhibition of quorum sensing autoinducers of oral disease-causing bacteria,
- wherein the oral disease-causing bacteria is Streptococcus mutans, and the D-galactose does not inhibit quorum sensing autoinducer of non-pathogenic normal oral flora which is one or more selected from the group consisting of Streptococcus oralis, Streptococcus salivarius, and Streotpcoccus mitis.
A method of inhibiting biofilm formation of oral disease-causing bacteria, the method comprising administering toothpaste containing D-galactose in an amount of 0.036 to 3.6% by weight to a buccal mucosa, a tooth, a gingiva, or a tongue of a subject in need of inhibition of biofilm formation of oral disease-causing bacteria,
- Wherein the oral disease-causing bacteria is Streptococcus mutans, and the D-galactose does not inhibit biofilm formation of non-pathogenic normal oral flora which is one or more selected from the group consisting of Streptococcus oralis, Streptococcus salivarius, and Streotpcoccus mitis.
A method of reducing virulence of oral disease-causing bacteria by inhibiting quorum sensing of the oral disease-causing bacteria, the method comprising administering toothpaste containing D-galactose in an amount of 0.036 to 3.6% by weight to a buccal mucosa, a tooth, a gingiva, or a tongue of a subject in need of reduction of virulence of oral disease-causing bacteria,
- wherein the oral disease-causing bacteria is Streptococcus mutans, and the D-galactose does not inhibit quorum sensing of non-pathogenic normal oral flora which is one or more selected from the group consisting of Streptococcus oralis, Streptococcus salivarius, and Streotpcoccus mitis.
A method of treating or ameliorating an oral bacterial disease by inhibiting quorum sensing of the oral disease-causing bacteria, the method comprising administering toothpaste containing D-galactose in an amount of 0.036 to 3.6% by weight to a buccal mucosa, a tooth, a gingiva, or a tongue of a subject in need of treating or ameliorating the oral bacterial disease,
- wherein the oral disease-causing bacteria is Streptococcus mutans, and the D-galactose does not inhibit quorum sensing of non-pathogenic normal oral flora which is one or more selected from the group consisting of Streptococcus oralis, Streptococcus salivarius, and Streotpcoccus mitis.
Dependencies are inferred from the claim text.