Small molecule therapeutic compounds that reduce the incidence of intracerebral hemorrhage and brain microhemorrhages

A method for reducing incidence of brain vascular leakage comprising administering to a subject in need thereof a pharmaceutical composition containing a small molecule therapeutic compound selected from artemether or a derivative of artemether, a therapeutic amount of which is effective to reduce incidence of bleeding in the brain by at least 30% relative to a control wherein the brain vascular leakage is brain microhemorrhage induced by administration of a statin, or the brain vascular leakage is a spontaneous intracerebral hemorrhage.