Inhibitors of multidrug resistance transporter P-glycoprotein
AssigneeSouthern Methodist University
InventorsJohn G. Wise, Pia D. Vogel, Alexander R. Lippert, Amila K. Nanyakkara, Maha A. Aljowni
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Abstract
The present disclosure provides a method of treating a subject that is resistant to one or more drugs by identifying a subject having one or more drug resistant cells; administering to the subject a pharmaceutically effective amount of an inhibitor compound, and contacting one or more drug resistant cells with the inhibitor compound to reduce the export of the inhibitor compound from the one or more drug resistant tumor cells and to block the transport of drug(s) from the one or more drug resistant cells.
Claims9
A method of treating a subject having cancer that is resistant to one or more chemotherapeutic drugs comprising the steps of:
- identifying a subject having one or more drug resistant prostate cancer cells that express a P-glycoprotein;
- administering to the subject a pharmaceutically effective amount of an inhibitor compound having one of the following structural formulas:
- contacting the one or more drug resistant prostate cancer cells with the inhibitor compound to reduce the drug resistance of the cancer cells.
Dependencies are inferred from the claim text.