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US 10,292,973 B2Granted
Covalent irreversible inhibitors of USP7 as anti-cancer agents
AssigneeProgenra, Inc.
InventorsJoseph Weinstock, Jian Wu, Suresh Kumar Kizhakkethil-George, Feng Wang, Matthew P. Kodrasov, Saket Agarwal
Life of this patent
Estimating the term…
Abstract
Compounds and pharmaceutical compositions for treating cancer by, for example, modulating immune system activity, are provided.
Claims27
A compound of formula (IV), including pharmaceutically acceptable salts, solvates and stereoisomeric forms thereof:
- wherein X is nitro or cyano;
- Y1 and Y2 may be the same or different and represent halogen, alkyl or haloalkyl;
- and
- R9 is selected from the group consisting of optionally substituted alkyl, cycloalkyl, heterocycle, heteroaryl, heteroarylalkyl, alkoxy, and aryloxy;
- Ra may be hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl.
2 more elements
A compound of formula (V), including pharmaceutically acceptable salts, solvates and stereoisomic forms thereof:
- wherein X is nitro or cyano;
- Y1 and Y2 may be the same or different and represent halogen, alkyl or haloalkyl;
- and
- R10 and R11 may be independently selected from the group consisting of H, halo, hydroxyl, and optionally substituted alkyl, aryl, alkoxy, aryloxy, heteroaryl, cycloalkyl, heteroarylalkyl, amino, alkoxyalkylamino, monoalkylamino, dialkylamino and dialkylaminoalkylamino;
- R12 may be hydrogen, optionally substituted alkyl or optionally substituted cycloalkyl;
- the dotted line represents a single bond or a double bond;
- and Y represents O or NH.
4 more elements
A compound of formula (VI), including pharmaceutically acceptable salts, solvates and stereoisomeric forms thereof:
- wherein X is nitro or cyano;
- Y1 and Y2 may be the same or different and represent halogen, alkyl or haloalkyl;
- R1 represents an optionally substituted 1,1-dioxidotetrahydro-2H-thiopyran-4-yl group, which may be fused to an optionally substituted aryl, cycloalkyl, heteroaryl or heterocyclic group;
- and R2 represents hydrogen or optionally substituted alkyl.
1 more element
Dependencies are inferred from the claim text.