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US 10,292,971 B2Granted
Tetrahydro-1H-pyrido[3,4-b]indole anti-estrogenic drugs
AssigneeOlema Pharmaceuticals, Inc.
InventorsDavid C. Myles, Peter J. Kushner, Cyrus L. Harmon
Life of this patent
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Abstract
The present disclosure provides tetrahydro-1H-pyrido[3,4-b]indole compounds or a pharmaceutically acceptable salt, solvate, hydrate, prodrug, stereoisomer, tautomer, rotamer, N-oxide and/or substituted derivative or, optionally in a pharmaceutical composition, for the modulation of disorders mediated by estrogen, or other disorders as more fully described herein.
Claims29
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- X is CH2— or —O—;
- Y is
- R1 and R2 are each hydrogen;
- R3 and R4 are each independently selected from hydrogen and halo, and when one of R3 or R4 is halo, the other of R3 or R4 is hydrogen;
- R5 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C0-C4(C3-C6 cycloalkyl), or C1-C6 heteroalkyl;
- R6 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, or C0-C4(C3-C6 cycloalkyl);
- and
- R7 and R8 are each independently selected from hydrogen and C1-C6 alkyl.
7 more elements
Dependencies are inferred from the claim text.