Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy

A method of lowering triglycerides in a subject on statin therapy having baseline fasting triglycerides of about 200 mg/dl to less than 500 mg/dl and a baseline fasting high density lipoprotein cholesterol (“HDL-C”) level of about 10 mg/dl to about 100 mg/dl, the method comprising determining a baseline fasting triglyceride level, a baseline fasting HDL-C level, and a baseline fasting Apolipoprotein B (“Apo B”) level associated with the subject;

• and thereafter administering to the subject about 2 grams or about 4 grams per day of ethyl eicosapentaenoate, wherein after the administering, an Apo B level associated with the subject decreases by at least about 5% compared to a second subject who has received statin therapy but not the ethyl eicosapentaenoate.