Pharmaceutical composition of ibuprofen and tramadol for ophthalmic use
OwnerFernando Martinez-Alzamora, Jose Miguel Rizo Martinez +3inventors
InventorsFernando Martinez-Alzamora, Jose Miguel Rizo Martinez, Antonia Gomez Calvo, Nuria Sanz Menendez, Angel Munoz Ruiz
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Abstract
The present invention relates to a pharmaceutical composition of ibuprofen and tramadol for ophthalmic use. Said composition is effective and safe for the treatment of ocular inflammation and/or pain associated to different diseases or pathological states which affect the eye area In particular, the ophthalmic composition of the invention is indicated, for example, for the treatment of pain and/or inflammation after eye surgery.
Claims11
An aqueous ophthalmic pharmaceutical composition comprising:
- a) ibuprofen arginate in a concentration of between 0.075% (w/v) and 0.14% (w/v), expressed as equivalent concentration of ibuprofen, wherein the molar ratio between ibuprofen:arginine is between 1.2:1 and 1:1.2;
- and
- b) tramadol, or a pharmaceutically acceptable salt thereof, in a concentration, expressed as equivalent concentration of tramadol hydrochloride, of between 0.25% (w/v) and 1% (w/v).
An aqueous ophthalmic pharmaceutical composition consisting of:
- a) ibuprofen arginate in a concentration of 0.1% (w/v), expressed as equivalent concentration of ibuprofen, wherein the molar ratio between ibuprofen:arginine is between 1.2:1 and 1:1.2;
- and
- b) tramadol, or a pharmaceutically acceptable salt thereof, in a concentration, expressed as equivalent concentration of tramadol hydrochloride, of 0.5% (w/v) as the active ingredients.
Dependencies are inferred from the claim text.