Pharmaceutical compositions for N-propargylamine derivative
AssigneeDr. Reddy's Laboratories, Inc.
InventorsChandrakant Bamtu Velip, Anup Avijit Choudhury, Girish Karanth, Rajeev Singh Raghuvanshi
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Abstract
The present application relates to a method of treating Parkinson's disease by administering a mouth-dissolving composition of N-propargylamine derivative, such as rasagiline or a pharmaceutically-acceptable salt thereof.
Claims18
A mouth dissolving composition of rasagiline or a pharmaceutically-acceptable salt thereof, comprising:
- (a) rasagiline in an amount less than or equal to 1 mg;
- (b) at least one sugar alcohol in an amount of 50% to 80% by weight of the composition;
- (c) at least two polymers of N-vinylpyrrolidone selected from the group consisting of crospovidone and copovidone, polyvinyl alcohol, polyvinyl acetate, copolymers thereof, and mixtures thereof, wherein the total amount of said polymers is present in an amount from about 0.2% to about 5.0% by weight of the composition;
- and
- (d) one or more pharmaceutically-acceptable excipients.
A method of treating Parkinson's disease in a patient in need thereof comprising administering to the patient a mouth dissolving composition of rasagiline or a pharmaceutically-acceptable salt thereof, wherein said composition comprises:
- (a) rasagiline in an amount less than or equal to 1 mg;
- (b) at least one sugar alcohol in an amount of 50% to 80% by weight of the composition;
- (c) at least two polymers of N-vinylpyrrolidone selected from the group consisting of crospovidone and copovidone, polyvinyl alcohol, polyvinyl acetate, copolymers thereof, and mixtures thereof, wherein the total amount of said polymers is present in an amount from about 0.2% to about 5.0% by weight of the composition;
- and
- (d) one or more pharmaceutically-acceptable excipients.
Dependencies are inferred from the claim text.