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US 10,292,931 B2Granted
Stable liquid pharmaceutical composition based on trazodone
AssigneeAziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.
InventorsMarcello Marchetti, Francesca Mariotti, Lorella Ragni, Paolo Scarpetti, Mauro Valenti
Life of this patent
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Abstract
A stable liquid pharmaceutical composition comprising an aqueous solution of a pharmaceutically acceptable salt of acid addition of trazodone, characterized in that said pharmaceutical composition has a pH value between 5.0 and 6.0, and comprises at least two cosolvents selected from the group comprising glycols and polyglycols.
Claims15
A liquid pharmaceutical composition, comprising:
- (a) water;
- (b) 6 to 8% w/v of trazodone hydrochloride;
- (c) propylene glycol;
- and
- (d) one or more cosolvents selected from the group consisting of polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 600, polyethylene glycol 1000, polyethylene glycol 1500, polyethylene glycol 3000;
- polyethylene glycol 3350, polyethylene glycol 4000, and polyethylene glycol 6000,
- wherein said liquid pharmaceutical composition is a solution and has a pH value of from 5.0 to 6.0, and said propylene glycol and said one or more cosolvents are present in a total amount of 45 to 90% w/v.
4 more elements
A liquid pharmaceutical composition, consisting of:
- (a) water;
- (b) 6 to 8% w/v of trazodone hydrochloride;
- (c) propylene glycol;
- (d) one or more cosolvents selected from the group consisting of polyethylene glycol 200, polyethylene glycol 300, polyethylene glycol 400, polyethylene glycol 600, polyethylene glycol 1000, polyethylene glycol 1500, polyethylene glycol 3000;
- polyethylene glycol 3350, polyethylene glycol 4000, and polyethylene glycol 6000, and
- (e) at least one additive selected from the group consisting of an antioxidant, a chelating agent, a buffer, a pH corrector, a surfactant, a cyclodextrin, a colorant, a sweetener, and a preservative;
- wherein said liquid pharmaceutical composition is a solution and has a pH value of from 5.0 to 6.0, and said propylene glycol and said one or more cosolvents are present in a total amount of 45 to 90% w/v.
4 more elements
Dependencies are inferred from the claim text.