Formulations for controlled release of bupivacaine
AssigneesThe University of North Carolina at Chapel Hill, Research Triangle Institute
InventorsLeah Marie Johnson, Ginger Denison Rothrock, Sarah Dorothy Shepherd, Sandra Cordel O'Buckley, Andrea Gail Neely
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Abstract
The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
Claims27
A biocompatible dental putty comprising a biodegradable hemostatic matrix having biodegradable microparticles dispersed therein, said biodegradable microparticles encapsulating a local anesthetic agent, wherein the biodegradable microparticles upon biodegradation thereof release the local anesthetic agent into the biodegradable hemostatic matrix and wherein the biodegradable hemostatic matrix is permeable to diffusion therethrough of the released local anesthetic agent, wherein the biodegradable microparticles have a loading of the local anesthetic of from 5% to 25% by weight, based on biodegradable microparticle weight, and wherein the biocompatible dental putty provides a biphasic release of the local anesthetic agent.
A biocompatible dental putty comprising a biodegradable gelatin hemostatic matrix having biodegradable poly-(lactic-co-glycolic) acid microparticles dispersed therein, said biodegradable poly-(lactic-co-glycolic) acid microparticles encapsulating a local anesthetic agent comprising bupivacaine or a basic form, salt, or enantiomer thereof, wherein the biodegradable microparticles upon biodegradation thereof release the local anesthetic agent into the biodegradable hemostatic matrix and wherein the biodegradable hemostatic matrix is permeable to diffusion therethrough of the released local anesthetic agent, wherein the biodegradable microparticles have a loading of the local anesthetic of from 5% to 25% by weight, based on biodegradable microparticle weight, and wherein the biocompatible dental putty provides a biphasic release of the local anesthetic agent.
Dependencies are inferred from the claim text.