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US 10,292,754 B2Granted
Therapeutic renal neuromodulation for treating dyspnea and associated systems and methods
AssigneeMedtronic Ardian Luxembourg S.a.r.l.
InventorPaul A. Sobotka
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Abstract
Methods for treating dyspnea with therapeutic renal neuromodulation and associated system and methods are disclosed herein. One aspect of the present technology, for example, is directed to methods that block, reduce, and/or inhibit renal sympathetic nerve activity to achieve a reduction in central sympathetic tone. Renal sympathetic nerve activity may be altered or modulated along the afferent and/or efferent pathway. The achieved reduction in central sympathetic tone may carry therapeutic benefits for patients with dyspnea.
Claims12
A method of treating a human patient diagnosed with dyspnea, the method comprising:
- intravascularly positioning a catheter carrying an energy transfer element within a renal artery and at least proximate renal nerves of the patient with diagnosed dyspnea,
- wherein, before therapy, the patient has a measured hypercapnic ventilatory response above a threshold value of 3 L/min/mmHgCO2;
- ablating the renal nerves of the patient via energy from the energy transfer element,
- wherein ablating the renal nerves at least partially reduces sympathetic neural activity in the renal nerves of the patient;
- and
- reducing central sympathetic drive in the patient in a manner that treats the patient for the dyspnea and reduces the patient's sensitivity to pCO2 such that the patient has a measured hypercapnic ventilatory response below the threshold value.
3 more elements
Dependencies are inferred from the claim text.