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AssigneeOmeros Corporation
InventorsGeorge A. Gaitanaris, John E. Bergmann, Alexander Gragerov, John Hohmann, Fusheng Li, Linda Madisen, Kellie L. McIlwain, Maria N. Pavlova, Demetri Vassilatis, Hongkui Zeng
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The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
A mouse comprising a first knockout mutation in a gene encoding a GPR85 polypeptide and a second knockout mutation in a gene encoding a SREB3 polypeptide.
A mouse cell comprising a first knockout mutation in a gene encoding a GPR85 polypeptide and a second knockout mutation in a gene encoding a SREB3 polypeptide.
Dependencies are inferred from the claim text.